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Principles of Biochemistry

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₦59,875.62

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Description

The Principles of Biochemistry course provides a comprehensive introduction to the molecular foundations of biological processes. Designed for students with a background in general chemistry, this course explores the structure, function, and interactions of biomolecules such as proteins, nucleic acids, lipids, and carbohydrates. It emphasizes the chemical principles underlying these biomolecules and their biological significance, integrating these concepts to thoroughly understand cellular functions and metabolic pathways.

Course Objectives:

  • Understand the structure and function of major biomolecules.
  • Explore enzyme mechanisms and kinetics.
  • Investigate the principles of thermodynamics as applied to biochemical reactions.
  • Examine metabolic pathways and their regulation.
  • Analyze the molecular basis of genetic information and its expression.
  • Apply biochemical techniques and methods to solve biological problems.

Key Topics Covered:

  1. Introduction to Biochemistry:
    • The central dogma of molecular biology.
    • Basic principles of chemistry applied to biological systems.
    • The importance of water and pH in biological contexts.
  2. Structure and Function of Biomolecules:
    • Amino acids, peptides, and proteins: structure, function, and dynamics.
    • Nucleic acids: DNA and RNA structure, replication, transcription, and translation.
    • Carbohydrates: classification, structure, and function in energy storage and cell recognition.
    • Lipids: types, structure, and roles in membranes and signaling.
  3. Enzyme Kinetics and Mechanism:
    • Enzyme structure and function.
    • Enzyme kinetics: Michaelis-Menten and allosteric regulation.
    • Mechanisms of enzyme action and inhibition.
  4. Metabolism:
    • Principles of metabolic pathways and energy transfer.
    • Catabolic and anabolic pathways: glycolysis, citric acid cycle, oxidative phosphorylation, and biosynthesis.
    • Regulation of metabolic pathways and integration of metabolism.
  5. Genetic Information and Expression:
    • DNA replication, repair, and recombination.
    • Gene expression and regulation: transcription factors, promoters, and enhancers.
    • RNA processing and translation.
  6. Biochemical Techniques:
    • Spectroscopy, chromatography, electrophoresis, and mass spectrometry.
    • Techniques for studying protein structure and function.
    • Methods for analyzing nucleic acids and gene expression.

Learning Outcomes: By the end of the course, students should be able to:

  • Describe the fundamental principles of biochemistry and their application to biological systems.
  • Analyze and interpret experimental data related to biochemical processes.
  • Understand the biochemical basis of health and disease.
  • Apply biochemical concepts to real-world problems and scenarios.

Assessment Methods: Assessment may include lectures, laboratory work, problem sets, quizzes, and exams. Students will be expected to understand and apply biochemical principles theoretically and practically.

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